From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models
Identifieur interne : 00C521 ( Main/Exploration ); précédent : 00C520; suivant : 00C522From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models
Auteurs : Vincent Goffin [France] ; Nadine Binart [France] ; Philippe Clément-Lacroix [France] ; Brigitte Bouchard [France] ; Christine Bole-Feysot [France] ; Marc Edery [France] ; Brian K. Lucas [France] ; Philippe Touraine [France] ; Alain Pezet [France] ; Ronda Maaskant [France] ; Caroline Pichard [France] ; Christine Helloco [France] ; Nathalie Baran [France] ; Hélène Favre [France] ; Sophie Bernichtein [France] ; Angélique Allamando [France] ; Christopher Ormandy [Australie] ; Paul A. Kelly [France]Source :
- Genetic Analysis: Biomolecular Engineering [ 1050-3862 ] ; 1999.
English descriptors
- KwdEn :
- Amino, Amino acids, Behavior, Binart, Binding site, Biol, Biol chem, Biomolecular, Biomolecular engineering, Bone formation, Bone metabolism, Candidate genes, Cdna, Chem, Cytokine, Cytokine receptor, Cytokine receptors, Cytoplasmic, Edery, Encoding, Endocrinol, Endocrinology, Exon, Gene, Genetic analysis, Isoform, Isoforms, JAK, Jak2, Kelly, Kinase, Knockout, Knockout mice, Lactation, Ligand, Mammary, Mammary gland development, Maternal behavior, Mouse, Mrna, Murine, Mutation, Osteoblast, Pathway, Phenotype, Phosphorylation, Prlr, Prlr animals, Prlr females, Prlr gene, Prlr knockout mice, Prlr knockout model, Prlr mice, Prlr mrna, Proc, Proc natl acad, Progesterone, Prolactin, Prolactin receptor, Pup, Receptor, Reproduction, Signaling, Stat, Structure, Tyrosine phosphorylation, Vertebrate.
- Teeft :
- Amino, Amino acids, Binart, Binding site, Biol, Biol chem, Biomolecular, Biomolecular engineering, Bone formation, Bone metabolism, Candidate genes, Cdna, Chem, Cytokine, Cytokine receptors, Cytoplasmic, Edery, Encoding, Endocrinol, Endocrinology, Exon, Gene, Genetic analysis, Isoform, Isoforms, Jak2, Kelly, Kinase, Knockout, Knockout mice, Lactation, Ligand, Mammary, Mammary gland development, Maternal behavior, Mouse, Mrna, Murine, Mutation, Osteoblast, Pathway, Phenotype, Phosphorylation, Prlr, Prlr animals, Prlr females, Prlr gene, Prlr knockout mice, Prlr knockout model, Prlr mice, Prlr mrna, Proc, Proc natl acad, Progesterone, Prolactin, Pup, Receptor, Tyrosine phosphorylation, Vertebrate.
Abstract
Abstract: Prolactin (PRL), a polypeptide hormone secreted mainly by the pituitary and, to a lesser extent, by peripheral tissues, affects more physiological processes than all other pituitary hormones combined since it is involved in>300 separate functions in vertebrates. Its main actions are related to lactation and reproduction. The initial step of PRL action is the binding to a specific membrane receptor, the PRLR, which belongs to the class 1 cytokine receptor superfamily. PRL-binding sites have been identified in a number of tissues and cell types in adult animals. Signal transduction by this receptor is mediated, at least in part, by two families of signaling molecules: Janus tyrosine kinases and signal transducers and activators of transcription (STATs). Disruption of the PRLR gene has provided a new mouse model with which to identify actions directly associated with PRL or any other PRLR ligands, such as placental lactogens. To date, several different phenotypes have been analyzed and are briefly described in this review. Coupled with the SAGE technique, this PRLR knockout model is being used to qualitatively and quantitatively evaluate the expression pattern of hepatic genes in two physiological situations: transcriptomes corresponding to livers from both wild type and PRLR KO mice are being compared, and following statistical analyses, candidate genes presenting a differential profile will be further characterized. Such a new approach will undoubtedly open future avenues of research for PRL targets. To date, no pathology linked to any mutation in the genes encoding PRL or its receptor have been identified. The development of genetic models provides new opportunities to understand how PRL can participate to the development of pathologies throughout life, as for example the initiation and progression of breast cancer.
Url:
DOI: 10.1016/S1050-3862(99)00025-X
Affiliations:
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xml:lang="fr">France</country><wicri:regionArea>INSERM Unité 344-Endocrinologie Moléculaire, Faculté de Médecine Necker, 156 rue de Vaugirard, 75730 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Maaskant, Ronda" sort="Maaskant, Ronda" uniqKey="Maaskant R" first="Ronda" last="Maaskant">Ronda Maaskant</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unité 344-Endocrinologie Moléculaire, Faculté de Médecine Necker, 156 rue de Vaugirard, 75730 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Pichard, Caroline" sort="Pichard, Caroline" uniqKey="Pichard C" first="Caroline" last="Pichard">Caroline Pichard</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unité 344-Endocrinologie Moléculaire, Faculté de Médecine Necker, 156 rue de Vaugirard, 75730 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Helloco, Christine" sort="Helloco, Christine" uniqKey="Helloco C" first="Christine" last="Helloco">Christine Helloco</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unité 344-Endocrinologie Moléculaire, Faculté de Médecine Necker, 156 rue de Vaugirard, 75730 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Baran, Nathalie" sort="Baran, Nathalie" uniqKey="Baran N" first="Nathalie" last="Baran">Nathalie Baran</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unité 344-Endocrinologie Moléculaire, Faculté de Médecine Necker, 156 rue de Vaugirard, 75730 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Favre, Helene" sort="Favre, Helene" uniqKey="Favre H" first="Hélène" last="Favre">Hélène Favre</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unité 344-Endocrinologie Moléculaire, Faculté de Médecine Necker, 156 rue de Vaugirard, 75730 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Bernichtein, Sophie" sort="Bernichtein, Sophie" uniqKey="Bernichtein S" first="Sophie" last="Bernichtein">Sophie Bernichtein</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unité 344-Endocrinologie Moléculaire, Faculté de Médecine Necker, 156 rue de Vaugirard, 75730 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Allamando, Angelique" sort="Allamando, Angelique" uniqKey="Allamando A" first="Angélique" last="Allamando">Angélique Allamando</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d’Expérimentation Animale et de Transgenèse, Faculté de Médecine Necker, 156 rue de Vaugirard, 75730 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Ormandy, Christopher" sort="Ormandy, Christopher" uniqKey="Ormandy C" first="Christopher" last="Ormandy">Christopher Ormandy</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Garvan Institute of Medical Research, St Vincent’s Hospital, 384, Victoria Street, Darlinghurst, Sydney, NSW 2010</wicri:regionArea><wicri:noRegion>NSW 2010</wicri:noRegion></affiliation></author><author><name sortKey="Kelly, Paul A" sort="Kelly, Paul A" uniqKey="Kelly P" first="Paul A" last="Kelly">Paul A. Kelly</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unité 344-Endocrinologie Moléculaire, Faculté de Médecine Necker, 156 rue de Vaugirard, 75730 Paris, Cedex 15</wicri:regionArea><wicri:noRegion>Cedex 15</wicri:noRegion><wicri:noRegion>Cedex 15</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Genetic Analysis: Biomolecular Engineering</title><title level="j" type="abbrev">GAT</title><idno type="ISSN">1050-3862</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">3–5</biblScope><biblScope unit="page" from="189">189</biblScope><biblScope unit="page" to="201">201</biblScope></imprint><idno type="ISSN">1050-3862</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1050-3862</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino</term><term>Amino acids</term><term>Behavior</term><term>Binart</term><term>Binding site</term><term>Biol</term><term>Biol chem</term><term>Biomolecular</term><term>Biomolecular engineering</term><term>Bone formation</term><term>Bone metabolism</term><term>Candidate genes</term><term>Cdna</term><term>Chem</term><term>Cytokine</term><term>Cytokine receptor</term><term>Cytokine receptors</term><term>Cytoplasmic</term><term>Edery</term><term>Encoding</term><term>Endocrinol</term><term>Endocrinology</term><term>Exon</term><term>Gene</term><term>Genetic analysis</term><term>Isoform</term><term>Isoforms</term><term>JAK</term><term>Jak2</term><term>Kelly</term><term>Kinase</term><term>Knockout</term><term>Knockout mice</term><term>Lactation</term><term>Ligand</term><term>Mammary</term><term>Mammary gland development</term><term>Maternal behavior</term><term>Mouse</term><term>Mrna</term><term>Murine</term><term>Mutation</term><term>Osteoblast</term><term>Pathway</term><term>Phenotype</term><term>Phosphorylation</term><term>Prlr</term><term>Prlr animals</term><term>Prlr females</term><term>Prlr gene</term><term>Prlr knockout mice</term><term>Prlr knockout model</term><term>Prlr mice</term><term>Prlr mrna</term><term>Proc</term><term>Proc natl acad</term><term>Progesterone</term><term>Prolactin</term><term>Prolactin receptor</term><term>Pup</term><term>Receptor</term><term>Reproduction</term><term>Signaling</term><term>Stat</term><term>Structure</term><term>Tyrosine phosphorylation</term><term>Vertebrate</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Amino</term><term>Amino acids</term><term>Binart</term><term>Binding site</term><term>Biol</term><term>Biol chem</term><term>Biomolecular</term><term>Biomolecular engineering</term><term>Bone formation</term><term>Bone metabolism</term><term>Candidate genes</term><term>Cdna</term><term>Chem</term><term>Cytokine</term><term>Cytokine receptors</term><term>Cytoplasmic</term><term>Edery</term><term>Encoding</term><term>Endocrinol</term><term>Endocrinology</term><term>Exon</term><term>Gene</term><term>Genetic analysis</term><term>Isoform</term><term>Isoforms</term><term>Jak2</term><term>Kelly</term><term>Kinase</term><term>Knockout</term><term>Knockout mice</term><term>Lactation</term><term>Ligand</term><term>Mammary</term><term>Mammary gland development</term><term>Maternal behavior</term><term>Mouse</term><term>Mrna</term><term>Murine</term><term>Mutation</term><term>Osteoblast</term><term>Pathway</term><term>Phenotype</term><term>Phosphorylation</term><term>Prlr</term><term>Prlr animals</term><term>Prlr females</term><term>Prlr gene</term><term>Prlr knockout mice</term><term>Prlr knockout model</term><term>Prlr mice</term><term>Prlr mrna</term><term>Proc</term><term>Proc natl acad</term><term>Progesterone</term><term>Prolactin</term><term>Pup</term><term>Receptor</term><term>Tyrosine phosphorylation</term><term>Vertebrate</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Prolactin (PRL), a polypeptide hormone secreted mainly by the pituitary and, to a lesser extent, by peripheral tissues, affects more physiological processes than all other pituitary hormones combined since it is involved in>300 separate functions in vertebrates. Its main actions are related to lactation and reproduction. The initial step of PRL action is the binding to a specific membrane receptor, the PRLR, which belongs to the class 1 cytokine receptor superfamily. PRL-binding sites have been identified in a number of tissues and cell types in adult animals. Signal transduction by this receptor is mediated, at least in part, by two families of signaling molecules: Janus tyrosine kinases and signal transducers and activators of transcription (STATs). Disruption of the PRLR gene has provided a new mouse model with which to identify actions directly associated with PRL or any other PRLR ligands, such as placental lactogens. To date, several different phenotypes have been analyzed and are briefly described in this review. Coupled with the SAGE technique, this PRLR knockout model is being used to qualitatively and quantitatively evaluate the expression pattern of hepatic genes in two physiological situations: transcriptomes corresponding to livers from both wild type and PRLR KO mice are being compared, and following statistical analyses, candidate genes presenting a differential profile will be further characterized. Such a new approach will undoubtedly open future avenues of research for PRL targets. To date, no pathology linked to any mutation in the genes encoding PRL or its receptor have been identified. The development of genetic models provides new opportunities to understand how PRL can participate to the development of pathologies throughout life, as for example the initiation and progression of breast cancer.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Goffin, Vincent" sort="Goffin, Vincent" uniqKey="Goffin V" first="Vincent" last="Goffin">Vincent Goffin</name></noRegion><name sortKey="Allamando, Angelique" sort="Allamando, Angelique" uniqKey="Allamando A" first="Angélique" last="Allamando">Angélique Allamando</name><name sortKey="Baran, Nathalie" sort="Baran, Nathalie" uniqKey="Baran N" first="Nathalie" last="Baran">Nathalie Baran</name><name sortKey="Bernichtein, Sophie" sort="Bernichtein, Sophie" uniqKey="Bernichtein S" first="Sophie" last="Bernichtein">Sophie Bernichtein</name><name sortKey="Binart, Nadine" sort="Binart, Nadine" uniqKey="Binart N" first="Nadine" last="Binart">Nadine Binart</name><name sortKey="Bole Feysot, Christine" sort="Bole Feysot, Christine" uniqKey="Bole Feysot C" first="Christine" last="Bole-Feysot">Christine Bole-Feysot</name><name sortKey="Bouchard, Brigitte" sort="Bouchard, Brigitte" uniqKey="Bouchard B" first="Brigitte" last="Bouchard">Brigitte Bouchard</name><name sortKey="Clement Lacroix, Philippe" sort="Clement Lacroix, Philippe" uniqKey="Clement Lacroix P" first="Philippe" last="Clément-Lacroix">Philippe Clément-Lacroix</name><name sortKey="Edery, Marc" sort="Edery, Marc" uniqKey="Edery M" first="Marc" last="Edery">Marc Edery</name><name sortKey="Favre, Helene" sort="Favre, Helene" uniqKey="Favre H" first="Hélène" last="Favre">Hélène Favre</name><name sortKey="Goffin, Vincent" sort="Goffin, Vincent" uniqKey="Goffin V" first="Vincent" last="Goffin">Vincent Goffin</name><name sortKey="Helloco, Christine" sort="Helloco, Christine" uniqKey="Helloco C" first="Christine" last="Helloco">Christine Helloco</name><name sortKey="Kelly, Paul A" sort="Kelly, Paul A" uniqKey="Kelly P" first="Paul A" last="Kelly">Paul A. Kelly</name><name sortKey="Lucas, Brian K" sort="Lucas, Brian K" uniqKey="Lucas B" first="Brian K" last="Lucas">Brian K. Lucas</name><name sortKey="Maaskant, Ronda" sort="Maaskant, Ronda" uniqKey="Maaskant R" first="Ronda" last="Maaskant">Ronda Maaskant</name><name sortKey="Pezet, Alain" sort="Pezet, Alain" uniqKey="Pezet A" first="Alain" last="Pezet">Alain Pezet</name><name sortKey="Pichard, Caroline" sort="Pichard, Caroline" uniqKey="Pichard C" first="Caroline" last="Pichard">Caroline Pichard</name><name sortKey="Touraine, Philippe" sort="Touraine, Philippe" uniqKey="Touraine P" first="Philippe" last="Touraine">Philippe Touraine</name></country><country name="Australie"><noRegion><name sortKey="Ormandy, Christopher" sort="Ormandy, Christopher" uniqKey="Ormandy C" first="Christopher" last="Ormandy">Christopher Ormandy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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